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6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione caronic anhydride aronicanhydride

Caronic anhydride

CAS: 67911-21-1

Molecular Formula: C7H8O3

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  5. 6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione caronic anhydride aronicanhydride

6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione caronic anhydride aronicanhydride - Names and Identifiers

Name Caronic anhydride
Synonyms aronicanhydride
Caronic anhydride
caronic anhydride
6,6-Dimethyl-3-oxabicyclo[3.1.]hexane-2,4-dione
6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione
3-Oxabicyclo[3.1.0]hexane-2,4-dione,6,6-diMethyl-
6,6-dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-quinone
6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione (Caronic anhydride)
6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione caronic anhydride aronicanhydride
CAS 67911-21-1
InChI InChI=1/C7H8O3/c1-7(2)3-4(7)6(9)10-5(3)8/h3-4H,1-2H3

6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione caronic anhydride aronicanhydride - Physico-chemical Properties

Molecular FormulaC7H8O3
Molar Mass140.14
Density1.274
Melting Point53-57℃
Boling Point246°C
Flash Point113°C
Solubility soluble in Methanol
Vapor Presure0.0274mmHg at 25°C
AppearanceWhite crystal
ColorWhite
Storage Conditionunder inert gas (nitrogen or Argon) at 2-8°C
SensitiveMoisture Sensitive
Refractive Index1.499
MDLMFCD09751198
Physical and Chemical PropertiesDensity 1.274

113 ℃

246 °c

6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione caronic anhydride aronicanhydride - Risk and Safety

Hazard ClassIRRITANT

6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione caronic anhydride aronicanhydride - Reference Information

Introduction caronic anhydride is also called 6, 6-dimethyl-3-oxabicyclo [3.1.0] hexane -2, 4-dione, a pharmaceutical intermediate, is mainly synthesized as an oral hepatitis C protease inhibitor Boceprevir. Boceprevir is an oral hepatitis C protease inhibitor developed by Schering-Plough.
Use caronic anhydride can be used as a pharmaceutical intermediate, mainly as the synthesis of oral hepatitis C protease inhibitor Boceprevir.
preparation Step 1: Add 200g of ethyl acetate in A ml flask, then add 94.8g(0.4mol) of ethyl dichloride to reduce
temperature to -5 ℃, starting with a flow rate of 2L/min, ozone with a volume concentration of 3% (the balance is air, the same below) is introduced for reaction,
during the reaction, the raw materials are subjected to medium-controlled analysis by gas spectrum, after the conversion rate of ethyl dichloride was greater than 99%, the ozone passage was stopped.
after the reaction is finished, water is added, the oil layer is washed with water and layered, 2 times, 100ml water each time, and the oil layer is concentrated by rotary evaporation after washing
The oil layer is depurified by the solvent, then, 70g of 30% liquid alkali is added dropwise to the residual material at the end of the reaction for saponification reaction. At this time, the PH
is greater than 12, and the reaction is maintained at a temperature of 50-60 ° C for 2hr, then, 30% hydrochloric acid was added dropwise to the reaction solution to acidify the reaction until
pH value was 1-2, and the reaction temperature was controlled at 40-50 ° C., and the reaction was maintained for 1hr. After dropping to room temperature, extract with methyl tert-butyl ether, 100ml each time, co-extract three times, combine the obtained organic layer solution, remove the solvent under vacuum and concentrate to obtain
3, 3-dimethyl-1, 2-cyclopropanedicarboxylic acid 57.3g,GC normalized content 98.2%, molar yield about 84%. Step 2: 50g of 3, 3-dimethyl-1, 2-cyclopropane dicarboxylic acid is added to the reaction bottle, and then 30g of acetic anhydride and 0.5g of sodium acetate are added, and then the temperature is raised to 170 degrees for reaction, after the end of the reaction, the temperature is lowered to 50-70 ℃, and 37.6g of product is obtained by desolvation under negative pressure. Then, 30ml of toluene and 90ml of petroleum ether are added for recrystallization, 33.2g of 6, 6-dimethyl-3-oxabicyclo [3.1.0] hexane-2, 4-dione were obtained, the normalized content was 99.6%, and the yield was
74.8%.
Last Update：2024-04-09 15:16:52
6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione caronic anhydride aronicanhydride
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Guangzhou Yuanda New Material Co.,Ltd
Featured ProductsMultiple SpecificationsSpot supply
Product Name: Caronic anhydride;6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione Request for quotation
CAS: 67911-21-1
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Email: 2470479589@qq.com
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Wuhan Boye Science And Technology Development Co., Ltd.
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Product Name: Caronic anhydride Request for quotation
CAS: 67911-21-1
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380 Click to send a QQ message
Wechat: 15387090420
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: Caronic anhydride Request for quotation
CAS: 67911-21-1
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Caronic anhydride Request for quotation
CAS: 67911-21-1
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Caronic Anhydride Visit Supplier Webpage Request for quotation
CAS: 67911-21-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Shanghai Yudiao Chemistry Technology Co.,Ltd
Product Name: Caronic anhydride Request for quotation
CAS: 67911-21-1
Tel: +86 021-37285211
Email: info@yudiaochem.com
Mobile: +86 18964703211
QQ: 122752498 Click to send a QQ message
Wechat: yudiaochem
Biocompounds Pharmaceutical Inc
Product Name: Caronic anhydride Request for quotation
CAS: 67911-21-1
Tel: 021-57687675-818
Email: rice@biocompounds.com
Mobile: 13817188755
QQ: 93115722 Click to send a QQ messageSend QQ message
ANQING PUHUA TRADING CO., LTD
Product Name: Caronic anhydride Request for quotation
CAS: 67911-21-1
Tel: 0556-5220409
Email: aqpuhua@163.com
Mobile: 18955619811
QQ: 316311 Click to send a QQ messageSend QQ message
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6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione caronic anhydride aronicanhydride
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